Possible Breakthrough in Fight against
Devil Facial Tumour Disease
April 2008
While
this rare communicable cancer known as Devil
Facial Tumour Disease (DFTD) threatens to wipe out the
iconic Tasmanian Devil. Researchers now believe they may have
found hope to keep this unique animal from facing extinction.
It
could be a major breakthrough and it is described as the most
exciting development to date. What's all the fuss about? It's
all about a Devil named Cedric which is the only devil to
show an immune response to DFTD.
Cedric
comes from the west coast region of the state which is currently
disease free. It is believed that Devils in this region may
have a different genetic makeup or major histocompatibility
complex (MHC). This means they may have a natural immune response
to the DFTD disease which is lacking in devils in the East
of the state in which MHC is so similar to the disease that
it does not recognise it as foreign and does not produce anibodies
to fight it.
This
seems to be the case with Cedric. Nine months ago Cedric and
his half brother Clinky were injected with dead DFTD cells.
Cedric produced antibodies while Clinky did not.
Cedric
and Clinky have the same mother, yet different fathers. The
difference between the two devils is their MHC. Clinky's MHC
like most devils so similar to the disease and is not recognising
it as an invader whereas Cedric is different and his immune
system did respond.
This
could mean that the Tasmanian Devil may be it's own saviour.
Two
months ago, the half-brothers were injected with live DFTD
cells. If Cedric remains healthy, while Clinky contracts the
disease, this would suggest that devils with Cedric's MHC
are DFTD-resistant or capable of responding to a vaccine.
It's
going to be a long wait and nervous wait for researchers including
Dr Woods, associate professor of immunology at the university's
Menzies Research Institute. The incubation period for the
disease is about six months and everything is hanging on this
one Devil named Cedric.
Story by
Debbie Thoy
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the Tasmanian Devil from Extinction. |
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